glutathione with l-cysteine The effects of the oral supplementation of L‐Cystine associated reduced L‐Glutathione‐GSH on human skin pigmentation: a randomized, double‐blinded, benchmark‐ and placebo‐controlled clinical trial - Duperray - 2022 L-Glutathione, Cysteine and Vitamin C

The cell lysates were precleared with 10 l of protein A/G agarose beads for 1 h

Abbreviations PTMs: Post-translational modifications PATs: Protein acyltransferases DHHC: Asp-His-His-Cys zDHHC: Zinc finger DHHC KAT/KDAC: Lysine acetyltransferase/lysine deacetylase NATs: N-terminal acetyltransferases SIRT3: Sirtuin 3 MAPK: Mitogen-activated protein kinase MKP1: MAPK phosphatase 1 MDM2: Mouse double minute 2 homolog KDAC: Lysine deacetylase TSA: Trichostatin A IFI16: Interferon-gamma-induced protein 16 NCOR/SMRT: Nuclear receptor corepressors COMT: Catechol-O-methyltransferase NK: Natural killer NKG2D: Natural killer group 2, member D CTCL: Cutaneous T-cell lymphoma PTCL: Peripheral T-cell lymphoma HAT: Histone acetyltransferase SDH: Succinate dehydrogenase TCA: Tricarboxylic acid cycle KGDHC: -Ketoglutarate dehydrogenase complex KAT2A/GCN5: Lysine acetyl-coenzyme A transferase 2A H3K79: Histone 3 lysine 79 -KG: Alpha-ketoglutarate CPT1A: Carnitine palmitoyltransferase 1A LDHA: Lactate dehydrogenase A K47: Lysine residue 47 H3K122: Histone 3 lysine 122 PGAM1: Phosphoglycerate mutase 1 GLS: Glutaminase SHMT2: Serine hydroxymethyltransferase 2 SDHA: Succinate dehydrogenase complex subunit A PKM2: Pyruvate kinase M2 PRMT5: Protein arginine methyltransferase 5 G6P: Glucose-6-phosphate CoAG6P: Coenzyme A glucose-6-phosphate SUCLA2VDAC3: Succinate-CoA ligase ADP-forming beta Subunit-voltage-dependent anion channel 3 SREBP-1CoA: Sterol regulatory element-binding protein-1 coenzyme A Fbw7 (FBXW7)SUCLA2: F-box and WD repeat-domain-containing 7 succinate-CoA Llgase ADP-forming beta subunit PGC-1SREBP-1: Peroxisome proliferator-activated receptor-gamma activator 1 alphasterol regulatory-element-binding protein-1 NF2Fbw7 (FBXW7): Neurofibromatosis type 2F-box and WD repeat-domain-containing 7 NMTsPGC-1: N-myristoyltransferase peroxisome-proliferator-activated Receptor-gamma coactivator 1 alpha PI3KNF2: Phosphoinositide 3-kinaseneurofibromatosis type 2 GAS41NMTs: Glioma-amplified sequence 41N-myristoyltransferases TNF-PI3K: Tumor necrosis factor-alpha phosphoinositide 3-kinase NDPGAS41: N-myristolytic downregulated protein glioma-amplified sequence 41 NUPTNF-: N-myristolytic upregulated protein tumor necrosis factor-alpha mTORNDP: Mammalian target of rapamycin N myristolytic downregulated protein AMLNUP: Acute myeloid leukemia N-myristolytic upregulated protein ICAM-1mTOR: Intracellular adhesion molecule 1 mammalian target of rapamycin FBXO4AML: F-box protein 4 acute myeloid leukemia PPT-1/2ICAM-1: Palmitoyl protein thioesterase 1/2 intracellular adhesion molecule 1 ABHD10/17FBXO4: / Hydrolase-domain-containing protein 10/17 F-box protein 4 FASNPPT-1/2: Fatty acid synthase palmitoyl protein thioesterase-1/2 EGFRABHD10/17: Growth factor receptor / hydrolase-domain-containing protein 10/17 PD-L1FASN: Programmed death ligand 1fatty acid synthase ACOX1EGFR: Acyl-coenzyme A oxidase 1epidermal growth factor receptor GLUT1PD-L1: Glucose transporter 1 programmed death ligand 1 NRasACOX1: Neuroblastoma RAS viral oncogene homologacyl-coenzyme A oxidase 1 GARS1GLUT1: Glycyl-tRNA synthetase 1glucose transporter 1 EVsNRas: Extracellular vesicle neuroblastoma RAS viral oncogene homolog CKAP4GARS1: Cytoskeleton-associated protein 4glycyl-tRNA synthetase 1 CD44EVs: Cluster of differentiation 44 extracellular vesicles STINGCKAP4: Stimulator of interferon gene cytoskeleton-associated protein 4 VDAC2CD44: Voltage-dependent anion channel 2 cluster of differentiation 44 PCSK9STING: Proprotein convertase subtilisin/kexin type 9 stimulator of interferon genes PTENVDAC2: Phosphatase and tensin homolog voltage-dependent anion channel 2 TeadsPCSK9: TEA domain transcription factor proprotein convertase subtilisin/kexin type 9 Tip60PTEN: TAT-interacting protein 60 phosphatase and tensin homolog SRCTeads: Steroid receptor coactivator TEA domain transcription factors ACAT1Tip60: Acetyl-CoA acetyltransferase 1TAT-interacting protein 60 CPT1ASRC: Carnitine palmitoyltransferase 1 asteroid receptor coactivator PATsACAT1: Protein acyltransferases acetyl-CoA acetyltransferase 1 ShhCPT1A: Sonic hedgehog carnitine palmitoyltransferase 1A HhatPATs: Hedgehog acyltransferase protein acyltransferases APTShh: Acyl protein thioesterase sonic hedgehog PPTHhat: Palmitoyl protein thioesterase hedgehog acyltransferase ABHD17A/B/CAPT: / Hydrolase-domain-containing protein 17A/B/cacyl protein thioesterase YEATSPPT: Yaf9, ENL, AF9, Taf14, and Sas5palmitoyl protein thioesterase BETABHD17A/B/C: Bromodomain and extraterminal / hydrolase-domain-containing protein 17A/B/C 2-BPYEATS: 2-Bromohexadecanoic acidYaf9, ENL, AF9, Taf14, and Sas5 BET: Bromodomain and extraterminal 2-BP: 2-Bromohexadecanoic acid References Bukiya AN, Dopico AM

These actions lead to BPC 157 potentially supporting immune balance

10.1038/sj.ijo.0801101

A.IsrarM.DuarteA