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To facilitate oxygen transport, RBCs carry about 66% of bodily iron in the prosthetic group of hemoglobin 6 , an evolutionary adaptation that promotes iron-dependent Fenton and Haber-Weiss chemistry, generating 1-2 mol/s of superoxide per liter of packed RBCs due to hemoglobin auto-oxidation, occurring at an estimated rate of 0.5-3% of hemoglobin per day 7