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However, while mechanistic insights from the aforementioned studies are based on the acute MPTP model, CD4 + T cell infiltration occurs earlier in the subacute model (208)

In HCC, this pathway is frequently upregulated due to mutations in CTNNB1 (encoding -catenin) or components of the degradation complex, such as AXIN1 and APC, leading to stabilization and nuclear accumulation of -catenin

This growing global distribution highlights the urgent need for early detection, preventive screening, and integrative approaches that address both disease management and long-term quality of life [3][2]