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The best-characterized vasodilator autacoids are nitric oxide (NO) and prostacyclin (PGI 2 ), but a substantial component of the vasodilator response observed in response to receptor-dependent agonists or increases in flow is insensitive to inhibitors of NO synthases and COXs

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Instead, it works to maintain the "redox balance," which is the healthy equilibrium between antioxidants and oxidants in the body

Aside from regulating the metabolism of iron and reactive oxygen species, nanomaterials can also trigger iron-dependent cell death by controlling GSH levels [139]