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Despite the pharmacokinetic limitations, irregular adsorption and fast catabolism, the l-dopa became the standard oral pharmaceutical therapy of PD in the last fifty years [7]

However, mutant or inactivated pRb (mt-pRb) cannot bind E2F, allowing uncontrolled activation of E2F targets and enabling cells to progress through the cell cycle independently of normal regulatory cues

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Finally, BPC 157 therapy has been tested in reliable experiments by taking a comparison of several application routes in the same model and obtaining congruence between various application routes, as requested proof (see Section 6)