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Furthermore, immunohistochemical analyses of the colon tissue sections revealed low protein expression levels of GCLC and GSS in normal mucosa, whereas diffuse and high expression levels of these proteins were detected in the cancerous tissue (Fig

Gene annotations were obtained from Genecard resource, and ontology analyses performed in Metascape [33] and ChEA3 [34]

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RSL3 can lead to the accumulation of intracellular GSH (Figure S4E), which might enhance drug efflux

FSP1 is a newly identified endogenous potent ferroptosis suppressor, which confers ferroptosis resistance through reducing coenzyme Q 10