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Resistance Mechanisms to Anti-Angiogenic Therapies in Cancer

Mdm2 inhibitor nutlin-3a induces p53-dependent apoptosis via transcription-dependent and independent pathways and overcomes fludarabine-resistance in CLL

Its stability and resistance to enzymatic degradation allow for consistent experimental evaluation, making it a valuable compound in controlled research models focused on regeneration and repair mechanisms

Cigarette smoke induces epithelial-to-mesenchymal transition, stemness, and metastasis in lung adenocarcinoma cells via upregulated RUNX-2/galectin-3 pathway