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Description

Accordingly, it provides an in-depth, stepwise account of how cancer cells acquire and catabolize carbohydrates, proteins, and lipids (hereby mostly triglycerides will be addressed) for energy, delineating the routes and control points under well-fed versus fasting states and evaluating where dietary interventions can plausibly constrain these fluxes

It has been established that the HMOX2 HW/GW mutant acts as an apo-HMOX2 mimic that allows us to study haem transfer dynamics, due to haem-binding at the HRM and the lack of haem in the catalytic core 49