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In addition to transcription factors mentioned above, there are also some other mechanisms involved in sorafenib resistance

Given that GPR146 is most highly expressed in mature adipocytes, obesity-associated changes such as increased immune infiltration and stromal remodeling may reduce the relative abundance of GPR146-expressing cells in bulk tissue profiles

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Another study shows that B cells are activated by CNS antigens after TBI (165)

Research in natural products and screening of plant-derived products are ongoing towards discovering natural agents for combating CT-induced organ toxicity