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Pharm Res 2013;30:217487 [DOI] [PMC free article] [PubMed] [Google Scholar] 15.Slitt AL, Cherrington NJ, Maher JM, Klaassen CD.Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites

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A significant pathogenic effect that increases neurotoxicity is the release of more systemic inflammatory mediators into the central nervous system due to damage to the BBB [10]