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4.1.3 Tryptophan and its metabolites Tryptophan, an essential amino acid, exhibits intimate associations with gut microbiota functions through its metabolic pathways, particularly the synthesis of 5-HT that plays a pivotal role in regulating the ENS ( Lactococcus , Streptococcus , Escherichia coli , and Akkermansia muciniphila , activate TPH1 in ECCs through SCFAs, catalyzing the conversion of tryptophan to 5-HT (Reigstad et al., 2015)

Lipophilic nutrients, including carotenoids, fat-soluble vitamins, phospholipids, and -3 PUFAs, are solubilized within yolk lipids, enhancing intestinal absorption and systemic distribution, often exceeding the bioefficacy of isolated supplements (5, 37)

Cysteine is oxidized to cystine which is readily transported into mammalian cells as a naturally occurring analog of cysteine 2

The 15-amino-acid peptide sequence (GEPPPGKPADDAGLV) is identical to standard BPC-157