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Role of the y-glutamyl cycle in the regulation of amino acid translocation

Ethical approval This article does not contain any studies with human and/or animal participants performed by any of the authors

ROS generates around 10,000 modifications in the DNA bases, resulting in dsDNA/ssDNA breaks, DNA intrastrand adducts, and cross-links to other molecules [40]

Moreover, SFN is considered to possess negligible toxic effects and effectively traverses the bloodbrain barrier in mice after intraperitoneal administration, potentially increasing brain-derived neurotrophic factor (BDNF) levels and enhancing dendritic spine density due to its direct impact on neurons, while also providing protection against oxidative stress via the Keap1-Nrf2 pathway (102)