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These findings highlight a previously unrecognized role of antioxidants and the glutathione system in the progression of malignant melanoma

Autophagy is a self-protective mechanism of cells, but lipid peroxidation disrupts the function of autophagy-related genes (e.g., Beclin-1, LC3), leading to autophagic decline, preventing the clearance of damaged mitochondria and protein complexes, and accelerating muscle cell death (5153)

Algal Res 24:237250 da Silva Vaz Jnr I, Imamura S, Ohashi K, Onuma M (2004) Cloning, expression and partial characterization of a Haemaphysalis longicornis and a Rhipicephalus appendiculatus glutathione S-transferase

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