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Sleep is critical to proper immune function, and ongoing sleep loss is linked to immunodeficiency

After TBI, increased glutamate release inhibits the normal function of System Xc-, thereby affecting GSH production and making it another ferroptosis pathway to consider in TBI (Guerriero et al., 2015)

Nature 414: 792798 [DOI] [PubMed] [Google Scholar] 101

From Della Toffola et al

, However, recent research has cast doubt on this theory by demonstrating that preserving superficial nerve branches during CTR does not lead to a reduction in local postoperative pain