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Upon binding to growth factors, these receptor tyrosine kinases are activated through dimerization and phosphorylation, which trigger the activation of three intracellular protein cascades: the RAS/RAF/MAPK (ERK) pathway, P13K/AKT pathway and PLC-/PKC pathway

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doi: 10.1371/journal.pone.0196120 147 BernutADupontCOgryzkoNVNeyretAHerrmannJ-LFlotoRAet al