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352 IL-21 can impair mitochondriaER contacts in Tregs from patients with CD, driving them into a hypermetabolic state and enhancing their proinflammatory responses

(II) The gamma-glutamylcysteine synthetase enzyme is the main rate-limiting step in this cycle, and this reaction is non-allosterically inhibited by physiologic concentrations of glutathione

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Tissue engineering of a human 3D in vitro tumor test system