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One potential reason for the poor long-term benefits of any therapy [for nail fungus] is that it may be treating only a manifestation of underlying disease(s), such as generalized immune suppression or peripheral micro- or macrovascular disease. Maybe fungal nail infections are just a manifestation of poor peripheral blood circulation that would normally allow your bodys natural defenses to keep the fungus from taking root in the first place

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10.1177/1120672119892804 Eur J Ophthalmol