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The hallmarks of cellular senescence, e.g., the appearance of senescence-associated -galactosidase (SA--gal) and heterochromatin foci (SAHF) as well as the increased expression of cell cycle inhibitor proteins, i.e., p16, p21, and p53, are also common markers of senescent immune cells, especially in Teff cells [154,155,156]

MI typically involves a sterile inflammatory response, with infarcted cardiomyocytes showing increased levels of NLRP3

Slice culture treatment Cuprizone powder ( bis -cyclohexanoneoxalyhydrazone) [Sigma, #C9012] was dissolved in 50% ethanol to a concentration of 0.1 M at 60C for 20 min with shaking, until complete dissolution

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Thus, our data further indicate that the increased mTORC1 signaling is a consequence of GSH depletion, but it is not sufficient to sustain humoral immunity