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Overall, they are very well-behaved

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Biological links between e-cigarettes and CVDs (Table 2) Oxidative stress Oxidative stress, regarded as the initiating factor of aging and a variety of diseases, is an imbalance state between the production of reactive oxygen species (ROS) and the endogenous antioxidant defense mechanisms [99]

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It's important to identify the main reason that is causing the irritation and make the changes to address it, such as adjusting nicotine levels, trying different PG/VG ratios, or exploring alternative e-liquids