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In fact in the face of such blows, Jerne says, 'it was difficult to maintain faith in the selective idea.' He explains 'It seemed unrewarding to present the case to real immunologists, as the instructive theory of antibody formation was firmly entrenched in those daysTo molecular biologists, furthermore, the Natural Selection Theory seemed appalling, because its assumption that protein molecules can be reproduced apparently violated their Central Dogma' (Jerne, 1966)

Visible tightening typically becomes apparent between weeks 8 and 12