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Reactive oxygen species (ROS) are produced in all cell types and function as cellular messengers in signal transduction, gene expression, and cell cycle regulation [7]

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These phosphorylation events (PTMs) destabilize the mitochondrial outer membrane, promote mitochondrial outer membrane permeabilization (MOMP), cytochrome c release and caspase activation, and directly reduce mitochondrial membrane potential (m) and ATP generation (57)

Munoz et al., 2012), and plays a role in controlling brain excitability (Kempson et al., 2014)

doi: 10.3389/fcell.2021.696542 77 ZhangAJiaZGuoXYangT