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Clinical studies consistently demonstrate a high prevalence of mental disorders among CVD patients, with depression affecting 20% - 30% of post-myocardial infarction cohorts and conferring a 2-fold increased mortality risk (HR = 2.24, 95% CI 1.85 - 2.71) [81]

J Clin Invest 123(9):36783684 Herranz D, Ambesi-Impiombato A, Sudderth J et al (2015) Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

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However, this flexibility comes at the cost of stability, which is maintained by a group of muscles known as the rotator cuff, because they are arranged like a cuff around the shoulder