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10.5487/tr.2013.29.4.235 212 SpillantiniM

Additionally, some studies, such as those involving oral doses of PBF-677 in healthy volunteers, employed dose-escalation methodologies to determine the maximum tolerated dose while closely monitoring for potential side effects (NCT02639975)

In an adult opioid-dependent animal model, other investigators have determined that withdrawal precipitates oxidative stress, and measures of oxidative stress directly relate to withdrawal behaviors, which are responsive to antioxidants