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[37] indicate that APO improves AHR, lowers the concentration of IL-4 and IL-13, and inhibits the activity of eosinophil peroxidase

Evidence suggests that Nurr1 and Pitx3 cooperate to regulate the expression of DA neurotrophic factors such as brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, as well as genes critical for DA neurotransmission, thereby promoting VTA DA neuron survival and the acquisition of mature DA phenotypes (Hegarty et al., 2013

In pathologies like gut microbiota dysbiosis or ischemia, circulating succinate levels rise, activating immune-cell SUCNR1 to drive inflammation (148)