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Neurobiol Aging 35 : 16861694

In CD, its pro-inflammatory LPS suppresses the bile acid transporter ASBT via TLR4 and MAPKc-Jun/c-Fos signaling, impairing bile acid reabsorption and exacerbating Clostridioides difficile infection (Yang et al., 2025)

Protonation of the amidecarbonyl makes it more electrophilic

Clin Cancer Res 27(11):3039-3049, 2021

To further validate this observation, we treated MTEC and 16HBE separately with cigarette smoke extract (CSE) and garlic oil, as well as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a compound also known as a key carcinogen in tobacco