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284 TNIK is a key regulator of the -catenin and TCF4 transcription complex, its pharmacological inhibition seems to be a promising therapeutic approach

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Synergy ideal but requires complementary mechanisms interacting favorably

COX-2 and prostaglandin regulation: Cyclooxygenase-2 produces pro-inflammatory prostaglandins

These receptors include retinoic acid-related orphan receptor (ROR), REV-ERB, and peroxisome proliferator-activated receptor (PPAR) (Oishi et al., 2005)