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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

Carter BZ, Mak DH, Schober WD, Koller E, Pinilla C, Vassilev LT, Reed JC, Andreeff M

Oh, and did we mention its paraben and SLS free

Access this article Similar content being viewed by others Abbreviations AIF: All ion fragmentation CID: Collision-induced dissociation m -CPP: 1-(3-Chlorophenyl)piperazine DDA: Data-dependent acquisition DMSO: Dimethyl sulfoxide ESM: Electronic supplemental material GSH: Glutathione GSH-EE: Glutathione ethyl ester HCD: Higher energy collisional dissociation HRMS: High-resolution mass spectrometer LC: Liquid chromatography LC-MS: Liquid chromatography-mass spectrometry MDF: Mass defect filter MRM: Multiple reaction monitoring MS: Mass spectrometry MS/MS: Tandem mass spectrometry NADPH: -Nicotinamide adenine dinucleotide 2-phosphate reduced tetrasodium salt NMR: Nuclear magnetic resonance RT: Retention time SIM: Selected ion monitoring S/N: Signal-to-noise XIC: Extracted ion chromatograms References Leung L, Kalgutkar AS, Obach RS

Levartovsky D, Lagziel A, Sperling O, Liberman U, Yaron M, Hosoya T, et al