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The latter frequently necessitate dose adjustment ( Table 44 ), a consideration particularly crucial for drugs with low therapeutic indices

Source: Lang, C

While early studies proposed that CSCs arise from NSCs or progenitor cells with oncogenic mutations, increasing evidence indicates that terminally differentiated cancer cells can reacquire stem-like properties under selective pressures such as hypoxia, inflammation, or therapeutic stress

Hcy triggers oxidative stress by multiple means, such as generating ROS directly through auto-oxidation with transition metals, activating oxidative pathways, and blocking antioxidant pathways (Perna et al., 2003

Our digestive system shares traits with both herbivores and carnivores