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An important distinction must therefore be made between orally administered VitC (OC), achieving maximum plasma concentrations of no more than 220 mol/L of blood, and pharmacological or high-dose IVC, generating plasma concentrations up into the millimolar range ( 15 mmol/L) [11,12,13], which is needed to kill cancer cells based on pre-clinical studies

The development of blocking antibodies and antibody-drug conjugates presents an alternative, perhaps a more viable approach to inhibiting glutamine uptake by regulating the ASCT2 transporter [109]

doi: 10.1007/s13197-021-05255-6 197

Although preclinical research indicates a favorable safety profile for BPC-157, even at high doses, the lack of comprehensive clinical data necessitates caution in research applications involving this peptide

Furthermore, a meta-analysis found that the risk of thiopurine-induced leukopenia was increased in 1136 NUDT15 R139C variant carriers compared with 4987 wild-type patients [odds ratio (OR) 6.9, 95% CI 5.29.1)