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There is no good quality clinical evidence from controlled studies in humans to suggest that GST polymorphisms affect paracetamol toxicity either at therapeutic or supra-therapeutic doses (see Table 4 in the supplementary data for a summary of the evidence)

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(2024) demonstrated in vitro and in vivo in gemcitabine-resistant cholangiocarcinoma (a biliary cancer model) that CBD induced ROS production (measured by DCFH-DA), ER stress (upregulating CHOP and ATF4), and apoptosis, significantly inhibiting tumor growth in xenografts (Pongking et al

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