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127 The discovery of a large number of NFE2L2 target genes (e.g., FTH1 , FTL , SLC40A1 , glutathione synthetase ( GSS ), GCLC , SLC7A11 , GPX4 , aldehyde dehydrogenase 3 family member A1 ( ALDH3A1 ), AKR1C , sestrin 2 ( SESN2 ) and ferrochelatase ( FECH )) further demonstrate the important antiferroptotic function of NFE2L2 128 (Fig