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15 HIF-1 consists of HIF-1 and HIF-1 subunits, which interact with the hypoxia-responsive element (HRE) to further modulate the expression of target genes

One-way ANOVA with Brown-Forsythe and Welch correction was performed when comparing multiple groups

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The HG group cells were cultured in DMEM containing 25 mmol/l glucose (Shanghai BasalMedia Technologies Co., Ltd.), 10% FBS and penicillin-streptomycin solution (100X)

Liver Int 35:23432353 Alqahtani SA, Kleiner DE, Ghabril M, Gu J, Hoofnagle JH, Rockey DC et al (2015) Identification and characterization of cefazolin-induced liver injury