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doi: 10.1038/s41467-019-12702-8 166 ZhangC.LiaoQ.ChenR.ZhuX

It is also noteworthy that blood and tissue levels of glutathione rise slowly and cumulatively only when large doses of it are administered orally

identified PERK as a specific receptor for TMAO, demonstrating that TMAO directly activates the PERK branch of the UPR at physiological concentrations, thereby inducing the transcription factor FoxO1, which is implicated in metabolic and inflammatory diseases (81)