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[] Enhancing mitophagy via the activation of PINK1Parkin signaling or the stabilization of hypoxia-sensitive receptors such as FUNDC1 offers alternative approaches for clearing dysfunctional mitochondria

Plant Cell Physiol 34:29135 Ding S, Lu Q, Zhang Y, Yang Z, Wen X, Zhang L, Lu C (2009) Enhanced sensitivity to oxidative stress in transgenic tobacco plants with decreased glutathione reductase activity leads to a decrease in ascorbate pool and ascorbate redox state

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96 Additionally, AMPK activation by reduced ATP levels maintains NADPH through inhibiting NADPH consumption in fatty-acid synthesis and enhancing NADPH production from fatty-acid oxidation instead of PPP to inhibit cell death