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These changes suggest a disruption in several metabolic pathways, including the biosynthesis of phosphatidylethanolamine, fatty acid synthesis, pyruvate metabolism, and mitochondrial acetyl group transfer, as indicated by pathway enrichment analysis

The dosages that researchers used in these studies ranged from 336 mg daily of cinnamon extract to 1500 mg daily in capsule form over 6 to 24 weeks, indicating the need for further investigations to determine the right dosing and duration of therapy