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This is considered in favor of the independent contribution of metabolic syndrome and its components (obesity, dyslipidemia, and hypertension), besides the hyperglycemia, to the onset and progression of DPN in T2D (33, 45, 107, 108)

Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells

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