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Description

Leucine and branched-chain amino acid metabolism contribute to the growth of bone sarcomas by regulating AMPK and mTORC1 signaling

Clarkson, B, Gaynor J, Little C, Berman E, Kempin S, Andreeff M , Gulati S, Cunningham I, Gee T

These processes appear to be dependent on the involvement of the mTOR signaling pathway

From the proteins perspective: MRP1 and MRP7 share three residues that interact with all the drugs: M339, I591, and T1241 in MRP1 correspond to G299, M546, and T1195 in MRP7 (Table 1, dark gray)