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Exogenous GH suppresses pulsatility and results in negative feedback

Advanced nanoparticle strategies for optimizing RNA therapeutic delivery in neurodegenerative disorders

Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion

This gives it a half-life long enough to support once-weekly dosing, a major practical advantage over earlier amylin-based therapies like pramlintide, which required multiple daily injections

Leydig cell aging (Zhang et al., 2020, Aging) FOXO4-DRI improved testosterone secretion and the testicular microenvironment in aged mice by clearing senescent Leydig cells