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Senolytic agents include natural compounds such as quercetin 13 or fisetin 14 , -galactosidase-activated nanoparticles and prodrugs 15,16,17 or compounds that target different vulnerabilities of senescent cells, such as HSP90 inhibitors 18 , cardiac glycosides 19,20 or NMT inhibitors 21

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Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

178 Overexpression of HSP27 is strongly associated with tumorigenesis, metastasis, and poor prognosis in various cancers, including head and neck squamous cell carcinoma, pediatric acute myeloid leukemia, breast cancer, and colorectal cancer

These compounds signal fibroblasts and endothelial cells to rebuild connective tissue and increase blood vessel formation, leading to faster wound healing and stronger tissue integrity