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Longitudinal data from Cardiff, Wales (19312008) demonstrated a steady increase in CD incidence, with rates nearly doubling each decade from 1.17 (19461955) to 7.09 (19761985), before levelling off at 5.88 (19861995) and 6.64 (19962005) 10 (Supplementary Fig

However, studies show that excess peroxidation of PUFAs (AA/ADA-OOH) does not explicitly indicate ferroptosis