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Instead, Seevers says, whats needed is a manufacturing process called aseptic processing, a much more difficult method that needs to be conducted under extremely well-controlled conditions

doi:10.1007/BF02002806

& Myasoedov, N.F

Anti-inflammatory effects Preclinical studies report reductions in inflammatory signaling, which could improve the local healing environment in acute injuries

This local vs systemic placement is a documented research practice pattern, not a proven clinical instruction the evidence for meaningfully different outcomes by placement is limited and largely preclinical