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It was originally developed as a potential treatment for obesity by researchers at Monash University

A study by Allen et al

However, mutant or inactivated pRb (mt-pRb) cannot bind E2F, allowing uncontrolled activation of E2F targets and enabling cells to progress through the cell cycle independently of normal regulatory cues

Following delivery of a therapeutic dose of paracetamol to a healthy person, the majority of paracetamol is directly conjugated in the liver by phase II enzymes to form glucuronide (APAP-glu) and sulphate (APAP-sul) derivatives