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That said, dosages up to 1,200 milligrams per day have been studied with no serious adverse effects reported. However, there isnt much long-term research with high doses of NMN, according to Jillian

Since supplemental B 12 can improve the GSH/GSSG ratio in clinical studies, we reanalyzed the difference in GSH/GSSG ratio across groups with B 12 as a covariate but the results did not changed, indicating that the difference in GSH/GSSG ratio across groups was not due to differences in serum B 12 concentrations

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Serum TBARS have been shown to be correlated with oxidative damage to certain tissues, namely heart and liver tissue at rest (Pearson Product Moment Correlation, or r = 0.71 to 1.0) and exercise (r = 0.68 to 0.99) [24]