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In painful diabetic neuropathy (PDN) rat model, subcutaneous injection of IGF-1 (2.5mg/kg) can relieve neuropathic pain[83]

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Pineda S, Bang OY, Saver JL, Starkman S, Yun SW, Liebeskind DS, Kim D, Ali LK, Shah SH, Ovbiagele B (2008) Association of Serum Bilirubin with ischemic stroke outcomes