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Eccentric acidizing can be implemented through either mechanical or chemical methods

Epilepsia 54 , 551563 (2013)

For Asn240Lys/Leu244Arg, the best docking poses suggest that all substrates can be orientated correctly within the active site since it exhibits the Phe260-substrate-His243 -stacking-system (Fig

Activated oxidative and nitrosative pathways may also lead to damaging mitochondrial membranes and DNA, thus reducing membrane fluidity (Chen and Yu 1994)