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Differences in gut microbiota between UC patients and healthy individuals The imbalance of intestinal flora UC is characterized by a decrease in bacterial diversity, especially in regions of active inflammation, specifically a reduction in the amounts and diversity of bacteria phyla Firmicutes and Bacteroides and an increase in the proportions of Enterobacteriaceae such as E coli [132]

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Riboflavin and PLP are also essential cofactors in the kynurenine pathway (Marashly and Bohlega, 2017), where adequate intake of these vitamins has been associated with production of kynurenic acid (Theofylaktopoulou et al., 2014), rather than quinolinic acid, which acts as an agonist to the NMDA receptor, thereby potentiating excitotoxicity (Zinger et al., 2011

A moderate number of newly formed blood capillaries (neovascularization) were seen in the surrounding tissue

Long term side effects, however, are possible