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Zoccali C, Torino C, Tripepi R, Tripepi G, DArrigo G, Postorino M, Gargani L, Sicari R, Picano E, Mallamaci F

Neutrophils can suppress intestinal inflammation in IBD patients by modulating immune responses, oxidative stress, and generating pro-inflammatory cytokines, chemokines, and calprotectin ( in vivo , has been shown in mouse experiments to ameliorate colitis by strengthening tight junction proteins, inhibit mitochondrial dysfunction during inflammation by enhancing lysosomal integrity, and limit the release of histone B for the purpose of maintaining homeostasis in the intestinal epithelium ( in vitro assay conducted by Yanjun Guo et al

Elevated L2HG sensitizes HCC cells to ferroptosis both in vitro and in vivo