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It is important to acknowledge that the effects and safety of MK-677 have not yet been thoroughly studied, necessitating caution when experimenting with the compound

In the present study, the activation of JNK, ERK1/2 and p38 signals was significantly increased in the EpCAM +/ + DSS group but not in the WT + DSS group, and importantly the activation of JNK and ERK1/2 was also higher in EpCAM +/ mice than WT mice (Figure 2C)