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Sleep improvements typically appear within 2-4 weeks, while body composition and performance changes develop over 2-3 months, with continued optimization through 6 months

However, RNA-seq-based aberrant expression (Supplementary Fig

Key Challenges Identified -Equinus deformity secondary to a previous tendo-Achilles injury persistent forefoot overload -Osteomyelitis of the metatarsal heads ongoing deep-seated infection -Large chronic ulcer with surrounding scar tissue due to multiple previous surgeries poor local biology and compliance issues -Simply dressing the wound was never going to be enough

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Immunity to invasive fungal diseases