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This paradox may be explained by the antioxidant paradox, where excessive scavenging of ROS disrupts their physiological role in capacitation and acrosome reaction (Dutta et al., 2022)

Activated fibroblasts produce matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), which play a crucial role in remodeling the extracellular matrix [27]